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KMID : 0043320160390121609
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Archives of Pharmacal Research
2016 Volume.39 No. 12 p.1609 ~ p.1620
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The role of Pin1 in the development and treatment of cancer
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Min Sang-Hyun
Zhou Xiao Zhen
Lu Kun Ping
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Abstract
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Protein phosphorylation and post-phosphorylation events regulate many cellular signaling pathways. Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolyl cis/trans isomerase that interacts with numerous oncogenic or tumor suppressive phosphorylated proteins, causes conformational changes in target proteins, and eventually regulates the activities of such proteins. These alterations in activity play a pivotal role in tumorigenesis. Since Pin1 is overexpressed and/or activated in various types of cancers, and the dysregulation of proline-directed phosphorylation contributes to tumorigenesis, Pin1 represents an attractive target for cancer therapy. This review will describe the role of Pin1 in cancer and the current status of Pin1 inhibitor development.
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KEYWORD
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Proline-directed phosphorylation, Cancer-driving pathways, Tumorigenesis, Pin1, Pin1 inhibitor, Prolyl isomerase
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